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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Diagnostic methods in helicobacter pylori infection : development, evaluation and application
(2006-11-30)
with the ensuing 3.3 years. The costs involved with H. pylori screening, eradication and gastrointestinal bleeding events were determined.
Results: The inhouse UBT was refined with reduced amount of radioactivity and the use of citric acid to enhance accuracy...
Cardiovascular risk factors, diet and the metabolic syndrome
(2006-09-01)
% of the subjects had at least one component of the metabolic syndrome and ~10% had the full syndrome (3 or more risk factors). Individuals with the metabolic syndrome had elevated concentrations of proinflammatory cytokines, a predominance of small dense LDL...
The impact of protein modification on immunogenicity and arthritogenicity
(2005-09-09)
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 1% of the Western world population. There are several theories regarding the etiopathogenesis.
The aim of this thesis was to study, ...
Mild head injury : inhospital observation or computed tomography?
(2005-11-25)
602 patients to either CT
imaging or inhospital observation. Patient outcome at 3-months was not
inferior for the CT strategy compared to inhospital observation, None of
the patients with normal findings on the acute CT scan later suffered...
Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro
(2005-05-03)
Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed.
Success ...
Responsiveness of human circulating phagocytes in relation to the inflammatory condition
(2004-09-24)
In the early stages of the inflammatory process, monocytes and granulocytes constitute important effector cells that must function correctly in order to clear infection. By activating leukocytes in vitro it is possible to ...
Studies on the regulation of human skeletal muscle lipolysis in vivo
(2004-11-12)
Intramuscular triglyceride deposits are a significant energy source, and are considered to be of importance in the pathogenesis of skeletal muscle insulin resistance. In contrast to adipose tissue, the lipolytic process ...
Regression on high-dimensional predictor space : with application in chemometrics and microarray data
(2004-11-26)
This thesis focuses on regression methodology for prediction and
classification in situations where there are many predictors but limited
number of observations. This situation is common in chemometrics and
microarray ...
Neurotrophic and immune regulatory factors in neuroinflammation
(2004-10-22)
into encephalitogenic TCRBV8S2+
and nonencephalitogenic TCRBV8S2 cells demonstrated higher inflammatory
cytokine mRNA levels in the encephalitogenic cells, whereas at peak of
disease the levels of brain-derived neurotrophic factor (BDNF) and
neurotrophin (NT)-3 were...