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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Biological aspects of synovial fluid mediated aseptic prosthesis loosening
(2005-08-26)
Aseptic prosthesis loosening is the most common reason for late failure of total hip arthroplasties. Resorption of the peri-prosthetic bone, resulting in a loose prosthesis is characteristic for aseptic loosening. The ...
Motivating clinical treatment of obesity : methods, education, supervision and outcome
(2004-11-05)
nearly doubled during the past 20 years and
now totals nearly 500 000. Obesity continued to increase in the Swedish
population between 1996/97 and 2000/01. In economic terms, the direct
health care cost may be approximately 2 % of the total expenditure...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Functional studies on the interaction of immunoglobulins with HIV-2 envelope
(2005-09-16)
Infection with HIV-2 has a much more limited geographic distribution than HIV-1, being less readily transmitted and is generally less pathogenic. The role of immunoglobulins in defence against pathogens in different body compartments is known, where...
Genetic modification of human natural killer cells and possible applications thereof
(2006-08-25)
Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2...
In vivo quantification of extrastriatal dopamine D2 receptors in the human brain
(2005-03-25)
The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. The brain imaging technology Positron...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis ...
Regulation of carbohydrate metabolism in skeletal muscle during and after contraction
(2006-11-03)
during exercise will lead to new strategies for treating or preventing increasingly prevalent diseases like type 2 diabetes. The aim of this thesis was to study the regulation of carbohydrate metabolism in skeletal muscle during and after contraction...
HIV-2 genetic evolution and viral dynamics
(2006-05-03)
HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients. However, why this lower viral load is seen is not known. In this thesis we have...