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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Studies on fat cell function in human obesity and insulin resistance
(2005-09-30)
Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks ...
The analgesic mechanisms of buprenorphine
(2006-01-13)
Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic ...
Safety limit estimation for cataract induced by ultraviolet radiation
(2005-08-12)
Background: Ultraviolet radiation (UVR) is considered one of the major risk factors for agerelated cataract. UVR-induced cataract follows a continuous dose-response function. The concepts maximum acceptable dose (MAD) and ...
The role of incretin peptides and ghrelin in upper gut motility and metabolic control
(2006-11-24)
Metabolic control is essential for the individual and is strictly regulated via a wide range of factors. One important mechanism in maintaining an adequate blood sugar level is the regulation of insulin release and gastric ...
Child health promotion : analyses of activities and policy processes in 25 Swedish municipalities
(2005-09-30)
The Swedish municipalities are important actors that offer appropriate
environments for healthpromoting activities directed at children and
adolescents. Enhanced understanding on how such activities develop is
needed ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
In vivo quantification of extrastriatal dopamine D2 receptors in the human brain
(2005-03-25)
The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. The brain imaging ...
Orthology and protein domain architecture evolution
(2006-05-22)
A major factor behind protein evolution is the ability of proteins to evolve new domain architectures that encode new functions. Protein domains are widely considered to constitute the "atoms" of protein chains, acting as ...
Development of nuclear medicine methods for gastric and small bowel motility : effects of GLP-1 on gastric emptying
(2005-05-20)
The diagnosis of functional disorders of the gastrointestinal (GI) tract
requires techniques being both sufficiently sensitive to detect
disturbances of the normal physiology and low-invasive enough not to
interfere ...