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The analgesic mechanisms of buprenorphine
(2006-01-13)
Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic ...
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(2021-07-29)
Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ...
Cryoablation of cardiac arrhythmias
(2011-10-18)
This thesis evaluates the safety and efficacy of cryoablation in supraventricular tachyarrhythmias.
In Study I, the acute and long-term outcome of cryoablation therapy of typical atrioventricular nodal reentrant ...