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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Health-related quality of life, treatment satisfaction and clinical aspects of patients with primary antibody deficiency receiving subcutaneous IgG self-infusions at home
(2006-10-20)
) every 2-4 weeks. While this treatment has proved to be effective and safe, it is cumbersome for patients: it may be difficult to find venous access, and they have to visit the hospital regularly to deal with repeated IVIG infusions. IgG serum levels...
Epstein-Barr virus latency in vivo and in vitro
(2006-10-06)
of EBV-DNA in 9 patients receiving allogeneic BMT. Four of 5 recipients of HLA-mismatched T-cell-depleted grafts showed a 4- to 5-log increase of EBV-DNA within 1 to 3 months after BMT. Administration of 2 to 4 infusions of 107 EBV-specific cytotoxic T...
Molecular genetic studies of oxidative stress related genes
(2005-08-31)
polymorphism at position –262 from the transcription start site in the human catalase gene. The C to T exchange was shown by reporter gene analysis and transient transfection to influence promoter activity. EMSA analysis showed that there is also a difference...
Tobacco smoking and periodontal health in a Saudi Arabian population
(2005-09-23)
. The questionnaire included information about oral hygiene practices, dental care and smoking habits. Of these subjects, 262 (73%) also volunteered for clinical examination, including assessments of oral hygiene, gingival inflammation and probing depth. Subgingival...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...
In vivo protein synthesis determinations in human immune cells
(2005-02-18)
of healthy volunteers. The isolated T lymphocytes responded with a 60% decrease of the protein synthesis rate from 9.4 ± 1.2 %/24 h to 3.8 ± 2.4 %/24 h, whereas the whole population of leukocytes showed an increase by 43% from 3.2 ± 1.2 %/24 h to 4.4 ± 1...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
, both 5HT2AR, being CD3, CD4 or CD8 positive cells, and serotonin transporter protein (SERT) positive cells, being CD1a, CD4, CD8 positive or CD56+ CD3- cells, were increased. 5-HT3R immunoreactivity was seen in the basal epidermis of the inflamed...
Platelets and eosinophils in lung tissue remodelling
(2006-08-25)
Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
is in strong linkage with -318C/T and is more frequently present in MG patients with thymoma. MG patients carrying -318C showed significantly decreased expression of CTLA-4 mRNA in non-stimulated cells. In the present study, the relationship of the expression...