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Health-related quality of life, treatment satisfaction and clinical aspects of patients with primary antibody deficiency receiving subcutaneous IgG self-infusions at home
(2006-10-20)
Patients with primary antibody deficiencies (PAD) are unable to produce sufficient amounts of antibodies and are therefore susceptible to severe bacterial infections. The standard therapy has been intravenous infusions of ...
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(2010-03-26)
Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and ...
Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology
(2008-01-11)
Lack of sufficient thyroid hormone during pregnancy and early postnatal
development results in profound mental retardation and motor deficits
whereas altered thyroid status in the adult is associated with disturbed
metabolic ...
Transcriptional regulation of cell life and death decisions by p73
(2013-03-05)
p73 is the second member to be identified within the p53 family and shares structure and functions with p53. P73 generates various isoforms, which include full-length transcriptionally active (TA) isoforms and amino-terminal ...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...