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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Characterization of the cellular receptor for coxsackievirus and adenovirus
(2006-08-25)
CAR, the cellular receptor for coxsackievirus and adenovirus, was discovered in 1997. CAR is an evolutionary conserved transmembrane protein that belongs to the CTX subfamily within the large immunoglobulin superfamily. ...
The functional role of the lateral olivocochlear system and mechanisms underlying sound condtioning
(2004-10-29)
Sound conditioning is a process induced by a low-level, non-damaging acoustic stimulus that provides protection against subsequent detrimental forms of acoustic trauma. Many hypotheses have been advanced to explain the ...
Modeling disturbances of cholinergic systems : possible relevance for schizophrenia
(2005-11-25)
projects has been to evaluate if disturbances in central cholinergic function can contribute to schizophrenic symptoms. In all studies an immunotoxin, 192 IgG-saporin (192-sap), was used to selectively kill cholinergic neurons in the basal forebrain...
Cellular immune responses against human parvovirus B19 infection
(2006-04-14)
The role of cellular immune responses in the control of Parvovirus B19 (B19) infection has not previously been investigated. B19 does not normally cause severe clinical problems but complications may arise in immunosuppressed ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Child health promotion : analyses of activities and policy processes in 25 Swedish municipalities
(2005-09-30)
The Swedish municipalities are important actors that offer appropriate
environments for healthpromoting activities directed at children and
adolescents. Enhanced understanding on how such activities develop is
needed ...
Physical fitness and overweight in Swedish youths
(2005-03-22)
The aim of the present thesis was to describe the level of physical fitness and prevalence of overweight and obesity in Swedish youths, and their trends over 14 years. Additionally, the relation between fitness and overweight ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...