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Characterization of the cellular receptor for coxsackievirus and adenovirus
(2006-08-25)
CAR, the cellular receptor for coxsackievirus and adenovirus, was discovered in 1997. CAR is an evolutionary conserved transmembrane protein that belongs to the CTX subfamily within the large immunoglobulin superfamily. ...
Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections
(2023-03-30)
In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo ...
T cell signatures and modulation by regulatory T cells
(2019-03-22)
CD4 T cells are crucial coordinators of protective immune responses against microbes and tumors. However, immune responses misdirected towards self-antigens are the hallmarks of autoimmune diseases. Regulatory T cells ...
Molecular characterization of apoptosis in B-cell chronic lymphocytic leukemia
(2005-03-18)
B-cell chronic lymphocytic leukemia (B-CLL), characterized by an accumulation of monclonal B cells, is the most common adult leukemia in the Western world. Defective apoptosis is considered to contribute to cell accumulation, ...
Antimicrobial and xenobiotic defence in the mammalian testis
(2012-05-24)
Different mechanisms exist in the mammalian testis to protect the germ cells from autoimmune attack, invading microbes, and xenobiotic induced toxicity, which would otherwise be deleterious to the preservation of fertility. ...