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Evaluation and treatment of pelvic organ prolapse : clinical, radiological and histopathological aspects
(2004-12-31)
Objective: To assess the use of cystodefecoperitoneography (CDP) in
clinical and radiological diagnosis of cystocele; to study the
correlation between clinical and radiological findings at CDP and to
evaluate if anatomical ...
Mercury exposure during early human development
(2005-03-11)
People are exposed to methylimercury (MeHg) mainly via consumption of fish, especially large predatory fish species. Inhaled mercury vapour (Hg0) released from dental amalgam fillings is the main source of exposure to ...
Breast cancer natural history models and risk prediction in mammography screening cohorts
(2022-03-31)
In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...
Endogenous and exogenous hormonal factors in female cancers : studies of risk and prognosis
(2009-02-06)
Extensive evidence points to hormonal influences which play a critical
role in the development and progression of breast, ovarian and
endometrial or uterine cancers. These cancers share many common hormonal
features, ...
Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity
(2005-03-11)
revealed higher locomotor activity, decreased habituation for locomotion, and lower anxiety levels in the Tg hsIL-1ra mice. The levels of DA, 5-HT, and their metabolites were decreased in certain brain regions of the Tg hsIL-1ra mice. IL-1 signalling...
Dissecting the roles of viral T-antigens in Merkel cell carcinoma
(2022-04-11)
Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced ...
Regulation of the vertebrate transcriptome in development and disease
(2016-01-15)
In the last decade we have seen a tremendous development in the omics area (genomics,
transcriptomics, proteomics etc.), making high throughput methods increasingly costeffective and available. The development in ...
Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases
(2019-12-18)
The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, ...
Mood disorders and consequences of pharmacological treatment
(2015-11-05)
Mental health issues are medical problems getting increased attention
throughout the world, and depression, only one among several types of
mental illnesses, are currently reported as the second leading cause of
disability ...
Every bug counts : neonatal colonization and infection of Gram-negative bacilli : aspects on antibiotic resistance in Sweden and Ecuador
(2020-09-18)
neonates (n= 14). The intestinal relative abundance of EPE was determined in each carrier. One fourth of the neonates were still carriers of EPE, two years after a NICU outbreak. The median length of colonization was 12.5 months. The low virulent but highly...