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Antibiotic resistance in Gram-negative bacilli : with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae
(2008-09-26)
Objectives: The objectives of this thesis were to study mechanisms
conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum
beta-lactamase) producing isolates of Escherichia coli and Klebsiella
pneumoniae, ...
Mood disorders and consequences of pharmacological treatment
(2015-11-05)
Mental health issues are medical problems getting increased attention
throughout the world, and depression, only one among several types of
mental illnesses, are currently reported as the second leading cause of
disability ...
Pulmonary manifestations in smoking-related diseases : clinical studies with emphasis on chronic obstructive pulmonary disease and rheumatoid arthritis
(2014-10-03)
Smoking is a risk factor for a number of diseases including chronic obstructive
pulmonary disease (COPD) and rheumatoid arthritis (RA). Cigarette smoke initiates
an inflammatory response which leads to structural changes ...
New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11
(2010-12-14)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) ...
Bereavement in adulthood and risks of incident and recurrent cardiovascular diseases
(2022-04-29)
Bereavement, the loss of a family member or a loved one, is a severely stressful life event that may occur at least once in most individuals’ life. Bereaved persons are likely to be influenced by the loss in multiple aspects ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs ...
Principles of transcriptional bursting in mammalian cells
(2023-05-22)
In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...
Precarious employment and occupational injuries in Sweden
(2022-02-23)
Nowadays, employment arrangements come under many different forms, often difficult to trace in the statistics due to a lack of standard definitions and measurements. Precarious Employment (PE) is a multidimensional construct ...