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Breast cancer natural history models and risk prediction in mammography screening cohorts
(2022-03-31)
In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...
Regulators of glucose and lipid metabolism in skeletal muscle and serum : implications for obesity and type 2 diabetes
(2012-11-01)
Type 2 diabetes mellitus (T2DM) has become a growing worldwide problem of public health importance. Insulin resistance is commonly associated with obesity and a key factor mediating the progression to T2DM. The failure of ...
Studies on the mechanisms of action and physiological relevance of SOCS proteins
(2011-10-27)
Understanding systemic biological pathways and the key cellular mechanisms that dictate disease states, drug response, and altered cellular function in metabolic disorders is a significant challenge. Research in the last ...
Car safety for children aged 4-12 : real world evaluations of long-term injury outcome, head injury causation scenarios, misuse, and pre-crash manoeuvre kinematics
(2013-05-14)
Child casualties in car crashes have decreased over the years. Nevertheless, occupant safety in rear seats, especially for children 4-12 years old, needs further attention because motor vehicle crashes remain the leading ...