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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Host responses and bacterial virulence factors in Neisseria infections
(2004-08-27)
Neisseria meningitidis and Neisseria gonorrhoeae are human specific pathogens. N. meningitidis is a major cause of meningitis and sepsis, whilst N. gonorrhoeae causes many millions of cases of gonorrhea in the world every ...
Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(2006-08-25)
Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ...
Cardiovascular risk factors, diet and the metabolic syndrome
(2006-09-01)
The clustering of metabolic disturbances, referred to as the metabolic syndrome, is today at the centre of attention. The rationale for this focus is that the prevalence of the metabolic syndrome is increasing globally ...
The natural history of HIV-1 infection and preparations for HIV vaccine trials in Tanzania
(2006-09-08)
useful information for HIV intervention strategies, including vaccine development.
Prevalence of sexually transmitted infections (STI's) at baseline among the workers was 16.6% (236/1422) and 15.5% (72/465) in males and females respectively, p=0...
Laparoscopic and open surgery for colon cancer : studies on costs and health related quality of life
(2006-05-19)
was estimated pre-operatively and 2, 4 and 12 weeks post-operatively by employing two validated HRQL instruments (EORTC QLQ-C30 and EQ-5D). Totally, 285 patients (130 LCR and 155 OCR) from 7 Swedish hospitals were included. In the QLQ-C30 instrument there were...
Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters
(2006-04-28)
The noradrenergic (NE), serotonergic (5-HT) and dopaminergic (DA) neurotransmission systems all have specific proteins responsible for the regulation of synaptic concentrations of neurotransmitter in the central nervous system (CNS...
Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors
(2004-09-03)
significantly promoted growth of cytogenetically normal cells from patients with 5q- syndrome, but had no effect on bone marrow from patients with other aberrations. RARS progenitors showed an aberrant accumulation of mitochondrial ferritin (MtF) already at day...
Standardization and application of quantitative PCR methods in patients with hematological malignancies
(2004-10-29)
difficult to detect against the background of regenerating bone marrow (BM).
The clinical definition of CR is traditionally based on conventional cytomorphological techniques, which have detection limits of 1-5%. Therefore more sensitive methods...
Parents with cancer : the experiences of family responsibility
(2004-11-12)
Then main aim of this study was to gain an understanding of how women and men with cancer illnesses, looking after children at home, experience and manage their life situation, with focus on the responsibility as parent. ...