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Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia
(2006-08-25)
Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult ...
Improving quality of life using mind-body therapies : the evaluation of a course intervention for personal self-awareness and development
(2009-02-19)
The general aim of this research project was to conduct a research
project in complementary alternative medicine (CAM), and to evaluate an
unusual course method. Since 1985 a special training centre, founded by
Bengt ...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% ...
Muscle composition, reach, physical activity and botulinum toxin treatment in children with cerebral palsy
(2018-11-09)
Cerebral palsy (CP), the most common cause of movement disorders and physical disability in children all over the world, is caused by an injury to the developing brain. Although this injury is not progressive, the ...
Metabolic and cognitive effects after early prenatal dexamethasone treatment
(2020-11-11)
Congenital adrenal hyperplasia (CAH), due to 21-hydroxylase deficiency (21OHD), is a disease with an inborn error of the adrenal steroid synthesis. This enzyme deficiency leads to cortisol shortage and androgen excess. If ...
From youth to adult : studies on chronic airway obstruction with special reference to events in the neonatal period
(2019-10-31)
Introduction: In western countries, 6-12% of all pregnancies end preterm, i.e. before 37 weeks of gestation. After the introduction of antenatal corticosteroids and improvements of neonatal intensive care, survival rates ...
Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell
(2016-01-28)
The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV)
channels to accomplish its unique function insulin secretion and to guarantee its viability.
Well-regulated β cell CaV channels ...
Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
(2001-05-18)
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2. The aim ...