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Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3
(2003-05-02)
of the tumors and by marker enrichment in the region of interest the common eliminated region I (CER1 or C3CER1) was reduced gradually to 1.6 cM on 3p21.3. Our aim was to further decrease the size of C3CER1 and identify the gene content. Additional markers were...
Multiple sclerosis linkage analysis and DNA variation in a complex trait
(2004-01-23)
was to investigate the three NOS genes NOS 1, NOS 2A and NOS 3 with regard to susceptibility and severity to MS in a case control dataset consisting of 92 severe cases and 92 mild cases and 148 controls. The aim was also to investigate the chromosomal regions of NOS...
Stiffness changes of the tympanic membrane in otitis media
(2002-05-03)
Acute purulent otitis media and otitis media with effusion, are common
diseases in childhood. Years later some of the children will get
"complications", such as retraction pockets and cholesteatoma, that often
need advanced ...
Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain
(2002-05-10)
) in microdialysates collected from freely moving animals and in tissues obtained from brain regions.
The most salient findings are: 1. Acute and chronic treatments with DA receptor antagonists affect NT-LI and NPY-LI in rat brain regions. Thus, haloperidol...
Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants
(2003-11-24)
is found in all organisms and consists of thioredoxin (TXN), thioredoxin reductase (TXNRD) and NADPH and it participates in many different types of reactions. Mammalian TXNRD1 is a selenoprotein containing a redox active selenocysteine residue and displays...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
RNA expression and amplification of the multidrug resistance gene (MDR-1). The MDR-1 gene amplification correlated also to the expression levels of the P-glycoprotein. In the doxorubicin resistant U-1285dox900 cells, the resistance correlated with the MRP1 gene...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
in 15 samples and found enzymes involved in the metabolism of environmental carcinogens, steroid hormones and drugs. A large interindividual variation in the expression of CYP1A1, 2A6, 2B6, 2D6 and 3A were shown whereas CYP1B1, 2C, 2E 1, 4A and 19...
Perinatal HIV-1 infection : aspects on clinical presentation, viral dynamics and epidemiology
(2004-09-15)
During the last 20 years HIV-1 infection has changed from being an
unknown disease to being a widespread pandemic, in some areas affecting a
large proportion of the human population. Mother-to-child transmission
(MTCT) ...
Enhancement of HIV-1 DNA immunogens
(2002-11-14)
Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. DNA vaccination...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
RDHs, CRAD1 and RDH5, revealed that they had short cytosolic tails of 6-7 amino acids. To examine the significance of these tails, we generated mutants with deleted tails. A reporter assay was developed to measure the enzyme activities of RDHs...