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Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants
(2003-11-24)
Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. ...
Acute and early chronic responses to resistance exercise using flywheel or weights
(2008-05-15)
Weight training typically offers constant external load during coupled shortening (concentric) and lengthening (eccentric) muscle actions in sets of consecutive repetitions until failure. However, skeletal muscle inherently ...
Studies of cohesin functions in the yeast and human DNA damage response
(2013-10-04)
Maintaining genome stability is critical to cell survival and normal cell growth and most human cancers display some form of genome instability. Genome instability is caused by multiple reasons and the ability to properly ...
Lumbopelvic pain during and after pregnancy : aspects of catastrophizing, fear-avoidance beliefs, physical ability and health-related quality of life
(2010-05-07)
Background: Every second pregnant woman suffers from lumbopelvic pain,
and many report remaining pain postpartum. Lumbopelvic pain affects the
woman s life in many ways and it is the main reason for sick leave ...
Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific B cell responses
(2019-11-21)
Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most ...
Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease
(2017-01-10)
Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in individuals ...
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
(2021-11-09)
Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, ...