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Dendritic cell and IgA responses in SIV and HIV-1 pathogenesis
(2004-04-28)
Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV-1) can infect different subsets of dendritic cells (DC). Such cells may therefore not only be involved in the generation of recruitment of ...
Immunogenetic studies in autoimmune endocrine diseases
(2003-11-25)
autoimmune process. The strongest genetic association identified is that with HLA class II genes located on the short arm of chromosome 6. It is well known that both HLA DRB1*04-DQA1*0301DQB1*0302 (DR4-DQ8) and DRB1*03DQA1*0501-DQB1*0201 (DR3-DQ2...
Prognosis in acute myeloid leukemia and influence of monocytic markers : epidemiological, clinical and experimental studies
(2003-04-04)
patients was 5.8 months and the probability of survival at 5 years was 9.3%. In a multivariate Cox proportional hazard analysis, age, LDH and kidney function were independent prognostic variables for survival. Cytogenetics was missing in many patients...
Etiological and clinical aspects of skin sensivity
(2003-11-14)
performed before and 3 months after the treatment. Thirty-one patients who were stinger positive before treatment showed decreased scores after treatment and only one patient had the same stinger score before and after treatment. The number of PGP 9...
Clinically important mycobacteria in Guinea-Bissau, West Africa : phenotypic and genetic diversity
(2004-09-24)
Tuberculosis (TB) is a major and still increasing health problem in West
Africa. In Guinea-Bissau, TB has an estimated annual incidence of
1501100.000. Knowledge on infections caused by nontuberculous
mycobacteria, such ...
The promotion of safe behaviours at the community level : evaluation of a bicycle helmet-wearing campaign among 5- to 12-year-old children
(2003-11-27)
among children aged 5-12 was implemented. The program's target was to increase the rate of helmet use from 1.3% before the program (1989) to 20% in 1993 and, thereby, to reduce the rate of bicycle-related head injuries leading to hospitalisation. The aim...
Disability and effects of weight loss in obese women
(2003-01-10)
INTRODUCTION: Obesity has become an important health problem world wide. It increases medical risks and affects daily living. Women are in the majority among obese persons seeking help. Standard recommendations on fitness ...
Nucleoside analog phosphorylation and mitochondrial enzymes : studies on molecular targets of the anti-leukemic compound 9-beta-D-arabinofuranosylguanine
(2004-03-26)
Nucleoside analogs are commonly used in treatment of cancer and viral infections. A way to improve the therapies would be to minimize the acquirement of resistance and side effects such as delayed cytotoxicity. Nucleoside ...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. From HLA-DQ molecules, DQ8 (DQA1*0301- DQB1*0302) is the most prevalent IDDM haplotype in Caucasians, followed by DQ2 (DQA1*0201-DQB1*0501). Taken together, DQ8, DQ2 or both account...
Polycystic ovary syndrome : a study of adipocyte lipolysis in relation to endocrine and metabolic status
(2003-05-14)
The aim of the present thesis was to obtain insight into possible regulatory effects of androgens on the regulation of lipolysis in subcutaneous as well as visceral adipose tissue in women with the polycystic ovary syndrome ...