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Nucleoside analog phosphorylation and mitochondrial enzymes : studies on molecular targets of the anti-leukemic compound 9-beta-D-arabinofuranosylguanine
(2004-03-26)
Nucleoside analogs are commonly used in treatment of cancer and viral infections. A way to improve the therapies would be to minimize the acquirement of resistance and side effects such as delayed cytotoxicity. Nucleoside ...
New pathogenic mechanisms in diabetic wound healing
(2012-11-01)
Diabetic foot ulcers (DFU) represent one of the most feared and invalidating complication of diabetes with high financial pressure for the healthcare system. For the moment there is no specific therapy available and it has ...
Regulation of cellular responses to hypoxia by HIF-1alpha-dependent and -independent signaling pathways
(2012-08-13)
Hypoxia is a state of inadequate oxygen supply to the cells and tissues of the body. It plays a critical role in embryonic development, as well as in various physiological and pathological processes. Hypoxia-inducible ...
Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina
(2020-11-09)
Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying ...