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Dendritic cell and IgA responses in SIV and HIV-1 pathogenesis
(2004-04-28)
Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV-1) can infect different subsets of dendritic cells (DC). Such cells may therefore not only be involved in the generation of recruitment of ...
Gender differences in chemical carcinogenesis
(2013-11-19)
Gender differences in cancer incidence and mortality is a regular finding in epidemiological studies. In addition to reproductive organs this pattern is also seen in non-reproductive organs, with men being the most affected ...
Assessment of HIF-1alpha function and identification of a novel degradation mechanism
(2009-05-22)
HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF-1alpha and ARNT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic ...
Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer
(2001-03-02)
Genes that are responsible for variations in drug and hormonal responses
are sometimes also associated with the pathophysiology of diseases.
Understanding the aetiology of a disease is often essential for the
design of ...
Glucocorticoid receptor function : interactions, mutants and ligand responses
(2008-05-08)
The protein that is investigated in this thesis is the glucocorticoid
receptor (GR), which belongs to the nuclear hormone receptor superfamily
of ligand activated transcription factors. The nuclear receptors share
three ...
Innate mechanisms in upper airway inflammation with focus on epithelium and neutrophils
(2017-04-27)
Mucosal inflammation is a key feature in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). The traditional idea of the epithelium as a simple barrier and neutrophils as a homogenous cell population, ...