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Matrix degrading proteases in vascular disease
(2002-11-22)
the impact of functional polymorphisms in the promoter regions of three different MMPs on abdominal aortic aneurysm, we found that the growth rate of aneurysms appears to be influenced by a variation in the MMP-2 gene. These results indicate that there is a...
Exercise and outcome measures in patients with polymyositis and dermatomyositis
(2003-08-22)
reduced disability. The intensive resistive 7-week exercise program resulted in significantly reduced muscular impairment without any signs of increased disease activity as assessed by muscle biopsies and CPK-levels. Both the MAP and the FI-2 had...
Comparison of stereotactic fine needle aspiration biopsy and core needle biopsy in breast lesions
(2004-04-16)
-FNAB and an average of three needle biopsies per lesion were taken. For S-CNB a needle with diameter 2.1 mm and 23 mm throw was used. Three needle biopsies per lesion were taken.
Paper I: Between May 1993 and June 1998 pre-operative S-FNAB and S-CNB were performed...
Apolipoprotein E and Alzheimer's diseases : signals and effects
(2002-04-26)
Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. ...
Case-crossover studies of the triggering of disease : myocardial infarction and Ménières disease
(2003-05-07)
-referent study including all cases of first-time MI (n=2,246) occurring in Stockholm County from 1992 to 1994; the Onset study, a case-crossover study of all eligible nonfatal cases (n=699) in SHEEP 1993 to 1994; and, the study of triggers of attacks of Ménières...
Physical activity and fitness among adolescents in Sweden with a 20-year trend perspective
(2003-10-03)
To prevent chronic diseases such as cardiovascular disease and type-2 diabetes, it is important to avoid body fatness, to remain physically active and to maintain aerobic fitness. It is also important to maintain a certain level of muscular strength...
Studies of genetic and environmental influences on Parkinson’s disease
(2004-01-30)
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Little is known about the etiology of PD. Although several PD genes are known, these are thought to be involved in ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...