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Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas
(2002-10-03)
of 20ql3, MDMX, MDM2 and Xq21 was detected at a relative low frequency (2-9%). Subsequent analyses showed that gene amplification was significantly correlated with aneuploidy and high proliferative activity. Co-amplification involving two or more genes...
Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis
(2003-09-26)
disease progression compared to the natural history data. As a consequence, the cost per QALY gained with 3-year treatment over a 10-year timeframe dropped from 342'700 SEK in the first study to 257'200 SEK in the second. When the model is applied...
Facilitation of recovery after ischaemic stroke : early dexamphetamine and physiotherapy treatment
(2003-11-28)
previously published studies. I) Forty-five patients, aged 18-85 years and included <72 hours after cerebral infarct, were randomised to d-amph (2.5 mg, 5 mg, or 10 mg) or placebo twice daily for five consecutive days. Safety of the drug was the primary...
The role of granulocyte antibodies in monocyte and granulocyte activation
(2003-02-21)
Granulocytes and monocytes are important cells during the first phase of inflammation. They are activated and recruited from the blood vessels to inflammatory sites via the regulation of receptors involved in adhesion to ...
Modelling biomolecular interactions
(2003-05-16)
Computational approaches for understanding and aiding in molecular biology has increased in significance over the last decades, where a wealth of biochemical experiments have provided a solid ground for developing computer ...
Intoxication of mammalian cells by the cytolethal distending toxin of Haemophilus ducreyi : a novel mechanism of action
(2001-09-14)
The cytolethal distending toxins (CDTs) are a newly described family of
bacterial protein toxins with a novel mechanism of action: DNA damage.
Haemophilus ducreyi produces a cytotoxin that belongs to this family.
This ...
Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1
(2003-08-29)
Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. Prostaglandin H synthase (PGHS) -1 or 2, also referred...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...
Wound ventilation : a new concept for prevention of complications in cardiac surgery
(2003-09-05)
it may cause dysfunction or permanent damage. 2) The wound is exposed to airborne bacterial contamination, which may lead to postoperative wound infection. 3) The wound is subjected to desiccation, which may lead to serious adhesions and possible...