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Facilitation of recovery after ischaemic stroke : early dexamphetamine and physiotherapy treatment
(2003-11-28)
Purpose: The overall aims of the thesis were to investigate the safety, efficacy, and pharmacokinetics of dexamphetamine (d-amph) after cerebral infarct, and the effects of different amounts of physiotherapy in combination ...
Inorganic and organic nitrates as sources of nitric oxide
(2012-05-15)
Inorganic nitrate (NO3-) and nitrite (NO2-) have generally been considered stable inactive end products of nitric oxide (NO) or unwanted residues in the food chain. While several recent studies surprisingly demonstrate ...
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Pelvic floor dysfunction depending on mode of delivery : clinical and epidemiological aspects
(2012-04-27)
Objective: To study pelvic floor disorders in relation to mode of delivery using clinical and epidemiological methods; to compare the prevalence and risk of lower urinary tract symptoms (LUTS) in healthy primiparous women ...
Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease
(2017-01-10)
Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in individuals ...
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
(2021-11-09)
Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, ...
Modelling and genetic correction of liver genetic diseases
(2021-03-24)
The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being ...
Identification of autoantigens in multiple sclerosis
(2023-01-04)
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system in which cells from primarily the adaptive immune system infiltrate the brain and spinal cord, leading to inflammation and demyelination. ...
Hypersexual disorder : clinical presentation and treatment
(2019-09-27)
Background: Persistent hypersexual behavior (HB) leading to negative consequences is a phenomenon that has lacked a recognized diagnosis in the psychiatric nomenclature, despite extensive study. Due to differences in the ...