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Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1
(2003-08-29)
Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. Prostaglandin H synthase ...
Characterization of ankyrin repeat domain 54 (ANKRD54) and its role on the regulation and subcellular localization of Bruton’s tyrosine kinase (BTK)
(2016-08-15)
Bruton's tyrosine kinase (BTK) is an important cytoplasmic signaling protein, where the kinase activity plays a pivotal role in the development, proliferation and differentiation of B-cell lineages. Ankyrin repeat domain ...
Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia
(2016-10-25)
Myeloproliferative neoplasms (MPNs) are a group of diseases characterized by hyperproliferation in the myeloid lineages of the bone marrow, leading to increased levels of circulating mature blood cells from one or more ...
Endothelial function in isolated small arteries from women at reproductive age and after menopause : possibilities for improvement
(2003-10-24)
Background: Alterations in vascular function are present in patients with Preeclampsia (PE) and in women after menopause. PE is a syndrome peculiar to human pregnancy that adversely affects the mother by endothelial ...
Angiostatic mechanisms of endogenous angiogenesis inhibitors
(2003-05-02)
Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor ...