Search
Now showing items 1-10 of 136
Implantation : morphological and biochemical characterization of the receptive human endometrium
(2002-09-27)
and that the pinopodes regress when the progesterone levels were decreasing. The pinopodes were found mainly on days 6 to 9 after the LH surge. The progesterone receptor B level decreased in epithelial cells concomitantly with the appearance of pinopodes. This study...
Functional studies on the nuclear receptor Nurr1
(2004-04-28)
The nuclear receptor (NR) superfamily comprises the largest family of ligand-activated transcription factors in eukaryotes, and it plays critical roles in many aspects of vertebrate development and physiology. The NR family ...
Uveal melanoma : cytogenetics, molecular biology and tumor immunology
(2002-09-13)
Uveal melanoma is the most common primary intraocular malignancy. The
metastatic spread is hematogenous and exclusively to the liver. Although
eye-sparing treatments are used more frequently the tumor-related
mortality ...
Endemic ataxic polyneuropathy in Nigeria
(2002-03-22)
.0 (15.9 -20.1), and 7.0 (4.3 - 9.7) in gari, which were processed using two different methods from cassava roots that contained 313.7 mg HCN eq/kg dry weight. Mean level of cyanogenic compounds dropped from 15 mg HCN eq/kg dry weight to 7 mg HCN eq...
Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human
(2004-01-29)
has a strong impact on CPA 4-hydroxylation.
The pharmacokinetics of CPA and its active 4-OH-CPA metabolite were
determined in patients with hematological malignancies and related to the
genotype of the CYP2B6, CYP2C9 and CYP2C19 genes...
Genetic background of familial primary hyperparathyroidism
(2003-04-11)
In this thesis the aim has been to identify and characterise gene(s) involved in familial primary hyperparathyroidism (PHPT). In multiple endocrine neoplasia type 1 (MEN 1), the hyperparathyroidism-jaw tumour syndrome ...
Mixed connective tissue disease, myositis and systemic lupus erythematosus : immunological and genetic studies in three related rheumatic autoimmune studies
(2002-11-28)
Mixed connective tissue disease (MCTD), polymyositis (PM)/ dermatomyositis (DM) and systemic lupus erythematosus (SLE) are chronic, rheumatic, systemic inflammatory disorders. The disorders depend on several factors of ...
Epidemiology and pathogenesis of HHV-6
(2002-01-04)
Human herpesvirus-6 (HHV-6), a beta-herpesvirus, was discovered in 1986. It is divided into two variants, A and B. HHV-6 variant B is the cause of exanthema subitum, while variant A has not yet been associated to any ...
Purification, structure and function of bioactive peptides
(2004-04-02)
by an isopeptide bond. In addition, NT(2-13) and NT(3-13) together with a fragment (22-38) of dopamine- and adenosine 3 ,5 -monophosphate-regulated phosphoprotein (DARPP-32) were also detected and studied by MALDI MS and Edman degradation. All the NT forms were...
Functional genomics at the interface of protein expression and biophysical analysis
(2004-02-18)
single cooperative unit. The low specific heat capacity change of 11 cal/(mol K residue) leads to a considerable flattening of the protein stability curve (deltaG (T)) and results in a maximal deltaG of 9.5 kcal/mol at 320K and a deltaG of 6.0 kcal...