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Functional genomics at the interface of protein expression and biophysical analysis
(2004-02-18)
Protein characterization is central to any functional genomics effort, hence protein expression and purification play fundamental roles in these initiatives. In this study strategies for protein expression in E. coli were ...
On the role of NMDA receptor subunits in the acute and chronic effects of nicotine
(2005-03-18)
Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy with other drugs of abuse, nicotine enhances dopamine (DA) neurotransmission within the mesocorticolimbic DA system. This ...
Mechanism of action of autosomal recessive juvenile parkinsonism gene mutations
(2010-01-29)
Parkinson Disease (PD) is the most common neurodegenerative movement disorder. Although PD is a largely sporadic disease, several genes has been linked to familial forms of PD. This thesis focuses on the mechanism of ...
Severe COVID-19 and routine biomarker patterns
(2023-10-10)
In acute infectious diseases, the composition of the blood changes. That includes
proteins, blood cells and smaller solutes. Routine blood tests have a fundamental role in
the diagnosis and follow-up of patients with ...