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Glucocorticoid administration : studies on weight regulation and metabolic implications
(2003-09-05)
Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have ...
Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines
(2004-04-02)
RNA expression and amplification of the multidrug resistance gene (MDR-1). The MDR-1 gene amplification correlated also to the expression levels of the P-glycoprotein. In the doxorubicin resistant U-1285dox900 cells, the resistance correlated with the MRP1 gene...
Mechanisms of regulation of dioxin receptor function
(2002-05-23)
is upregulation of genes encoding drug metabolizing enzymes such as Cythochrome P4501A1 and 1A2. Another effect of dioxin-exposure in intact cells is down-regulation of gap junction-mediated cell communication.
We are here able to show that this effect is due...
Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects
(2002-09-11)
.
The aim of the present studies was to analyse the mechanistic aspects involved in the adenosine A1/dopamine D1 and adenosine A2A/dopamine D2 intramembrane receptor-receptor interactions at the cellular and molecular level. The results from studies...
K+ channels in the inner ear : electrophysiological and molecular studies
(2005-02-17)
channel proteins within the cochlea was investigated using immunohistochemistry. Antibodies against KCNQ2 and KCNQ3 stained both spiral ganglion cells types (type 1 and 11), and their afferents projecting to the sensory inner and outer hair cells...
Genetic dissection of multifactorial disease models in the rat
(2002-08-26)
weight. The first genome-wide scan with 253 markers revealed three glucose-related loci, Niddm I (LOD 11), Niddm2 (LOD 4.5) and Niddm3 (LOD 4.6), and one locus, Weight1 (LOD 6.2), for body weight on chromosomes 1, 2, 10, and 7 respectively, supporting...
Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study
(2002-08-23)
inhibitors (SSRIs); an effect suggested to result from an antagonistic action of pindolol on somatodendritic 5-HT1A autoreceptors, reversing the acute, inhibitory, effect of SSRIs on serotonergic neuronal activity. However, upon systemic administration...
Trombolys och biokemiska markörer : i den prehospitala fasen av akuta koronara syndrom
(2003-05-16)
thrombolysis on a national basis in Sweden appears to be safe. Six patients (4%) had cardiac arrest prior to hospital admission and 2 (1 %) died prior to arrival at hospital. One patient was given treatment despite an exclusion criterion (previous stroke...
Smoking cessation during pregnancy
(2001-11-02)
-intervention study.
Of 582 women enlisted at the ANCs, 433 (74%) were included. 253 (58%) women and 230 (53%) partners responded. Thirty percent of the women were smokers at the start of pregnancy, compared with 25% of the men. During pregnancy 18% continued...
Biomolecular characterization of mumps virus genotypes with varying neurovirulence
(2002-05-09)
Mumps virus is an RNA virus, which belongs to the Rubula virus genus of the family Paramyxoviridae. Mumps is a common childhood infection. Classically, mumps infection presents as parotitis although it is frequently ...