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Mechanisms of regulation of dioxin receptor function
(2002-05-23)
The dioxin receptor is a ligand-inducible transcription factor that belongs to the basic helix-loop- helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The dioxin receptor is regulated in a spatial manner, where ...
Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma
(2016-10-05)
Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...