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Biomolecular characterization of mumps virus genotypes with varying neurovirulence
(2002-05-09)
Mumps virus is an RNA virus, which belongs to the Rubula virus genus of the family Paramyxoviridae. Mumps is a common childhood infection. Classically, mumps infection presents as parotitis although it is frequently ...
Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis
(2005-08-17)
In a murine model of contact allergy, 24 h after challenge with antigen, increased axonal growth using an antibody to growth-associated protein-43 (GAP-43) was seen in the epidermis and dermis of eczematous skin. Protein ...
Pharmacokinetic and pharmacodynamic aspects on opioid administration, morphine and ketobemidone, in the pediatric population
(2012-10-23)
Opioids are the mainstay of the treatment of severe nociceptive pain in both children and adults. The studies in this thesis have focused on different aspects of opioid treatment in the pediatric population with special ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Bioactive peptides and proteins in disease
(2004-05-17)
Regulatory peptides and marker proteins are important to study in order to understand disease mechanisms. This applies of course also to our common diseases where all relationships are not yet known. Cancer and diabetes ...
Identification and evaluation of novel prognostic genetic markers for childhood acute lymphoblastic leukemia
(2017-03-02)
Childhood acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer today. Due to advances in risk stratification and treatment, survival rates have increased drastically the last decades. Currently, ...
Genetic and immunological studies of experimental arthritis, with emphasis on a novel C-type lectin receptor gene complex
(2009-03-05)
Rheumatoid Arthritis (RA) is a chronic, systemic autoimmune syndrome primarily affecting peripheral joints. The etiology of RA is largely unknown but complex interactions between genetic and environmental factors contribute ...
Coagulation in liver failure : the role of thromboelastometry and fibrinogen
(2020-11-06)
Liver failure is undeniably accompanied by distortions of the coagulation system. The modern theory of coagulation in patients with compensated liver disease (acute or chronic) states that the coagulation system is in a ...
Aspects of diverting stoma and ERAS in rectal cancer surgery
(2016-04-25)
Annually, nearly 2000 patients are diagnosed with rectal cancer in Sweden. To date, the only known curative treatment is surgery and low anterior resection (LAR) is the operation of choice for tumours in the middle rectum. ...
Infection early in life and risk of non-affective psychosis
(2015-04-07)
In light of the increasing, but insufficient, evidence that various infections and immunological processes during brain development are associated with psychotic disorder, the aim of this thesis was to investigate infection ...