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Molecular genetic studies of human thyroid tumors
(2001-08-17)
Tumors of the thyroid gland are common among the general population, but only a small proportion is malignant. The vast majority of thyroid tumors are benign, so called follicular adenomas. Sometimes subtypes such as ...
Retinol dehydrogenases in retinoid metabolism : studies on a 9-cis/11-cis-retinol dehydrogenase in adult and embryonic tissues
(2000-09-15)
underlying the generation of active retinoid metabolites in both embryonic and adult tissues. Novel retinol dehydrogenases belonging to the short-chain dehydrogenase/reductase (SDR) family were identified using a RT-PCR screening procedure. RDH4, a 32 k...
Regulation of B cell responses to modified self
(2013-10-25)
The immune system needs to be efficient to protect organisms from invading pathogens. Lymphoid organs such as the spleen and lymph nodes are needed to initiate the response. The spleen is important for systemic immunity ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
generates reactive aldehydes that modify proteins. Two important aldehydes are malondialdehyde (MDA) and 4-hydroxynonenal, which can form covalent adducts on proteins. To analyze the mechanisms for the activation of T cells by aldehyde-modified proteins...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
to refer to total NH3 and NH+ 4 levels) which is an important diagnostic bioanalyte. Ammonia production by urease producing gut bacteria is a major contributor to blood ammonia levels and must be effectively detoxified by the liver for excretion...
Healthcare financing challenges and opportunities to achieving universal health coverage in the low- and middle-income country context
(2020-02-05)
uninsured to use MTP for healthcare. Applying the two-part regression model in study IV, we found that in comparison with the uninsured, the average OOP payment was 6.4% (p<0.001) smaller among the insured for such healthcare utilization. Nonetheless...
Exploration of large molecular datasets using global gene networks : computational methods and tools
(2019-08-02)
IP-seq dataset suggested that Foxa2 directly regulated more than 250 genes expressed by the floor plate and identified Rfx4 and Ascl1 as co-regulators of many floor plate genes. Experimental studies suggested a cooperative activator function for Foxa2 and Rfx4...
Modelling and quantifying brain connectivity and dynamics with applications in aging and ADHD
(2019-10-04)
Human brain is a complex organ and made up of integrative networks encompassing a large number of regions. These regions communicate with each other to share information involved in complex cognitive processes. Functional ...