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Molecular aspects of tau proteins in Alzheimer's disease and frontotemporal dementia
(2001-09-07)
Due to aggregation in the brain of dysfunctional tau proteins, both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are referred to as tauopathies, an entity also including a number of other neurodegenerative ...
Improved malaria case management in under-fives in the era of Artemisinin-based combination therapy in Tanzania
(2010-05-26)
Early parasite-based diagnosis of malaria prior to treatment is critical for rational drug use, optimal outcome of febrile illness, patient adherence, prevention of parasite drug resistance, and reduced costs of health ...
Chemical genetics and immunomodulation in Salmonella enterica serovar typhimurium infection
(2015-04-08)
Salmonella sp. are versatile bacteria that survive and replicate in a plethora of environmental
niches and hosts, including humans. The illnesses caused by various serovars in humans
range from mild gastroenteritis to ...
Nuclear hormone receptors studied by molecular dynamics computer simulations
(2004-03-05)
Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. The ...
On the detection and management of urinary bladder carcinoma
(2008-11-07)
cancer. In contrast, patients with TaG3 or T1G2-G3, after five years of follow-up, had a cancer-specific death rate of 30%. Patients with TaG3 or T1G2-G3 in whom random bladder biopsies were performed were more likely to be treated with intravesical BCG...
Plasma cell malignancies in Sweden : subgroup descriptions and regional outcomes for multiple myeloma
(2022-04-13)
Plasma cell disorders appear in various forms such as aggressive plasma cell leukemia (PCL), typical symptomatic multiple myeloma (MM), non-symptomatic smouldering multiple myeloma (SMM) and solitary plasmacytoma (SP). The ...
Significance of adipose tissue characteristics for development of metabolic complications in obesity
(2014-11-14)
controlled trial, investigated the 2-year effects of omentectomy in conjunction with gastric bypass operation on insulin sensitivity and the lipid profile. Eighty-one subjects were included in the study and 62 were re-examined two years post...
Structural and functional studies of Malassezia sympodialis-derived allergens
(2008-03-21)
Atopic eczema (AE) is a chronic inflammatory skin disease characterised
by pruritic (itchy) skin lesions. The pathogenic mechanisms underlying AE
are still unclear, although several factors such as genetic
predisposition, ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
significantly higher rate of intrapartum cesarean section among women ≥40 years, both after spontaneous onset of labor (adjusted odds ratio (aOR) 3.07, 95%CI 2.81-3.35) and induction of labor (aOR 2.51, 95%CI 2.24-2.81). The risk of VE was also increased...
Erythrocyte amino acids in health and renal failure and their association to the IGF-I/IGFBP-1 axis
(1998-11-13)
Abnormalities in amino acids (AA) metabolism in uraemia have mainly been reported to occur in plasma and muscle. No investigation has been undertaken to evaluate the AA levels in plasma, muscle and red blood cells (RBC) ...