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Notch receptor processing and CNS disease
(2002-08-30)
We have studied the relationship of Notch receptor processing and two diseases of the central nervous system: Alzheimer's disease (AD) and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy ...
Nuclear hormone receptors studied by molecular dynamics computer simulations
(2004-03-05)
Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. The ...
Altered cell metabolism and migration in nasopharyngeal carcinoma
(2021-10-29)
Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, ...
CYP2C19 polymorphisms in drug metabolism and response
(2014-11-13)
Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience ...
Shoulder injuries in adolescent elite handball players
(2019-10-04)
Background: Handball is a physically demanding sport that includes jumping, running, side-cutting movements and frequent throwing. A high prevalence of shoulder problems and pain has been reported in adult handball players ...