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Significance of adipose tissue characteristics for development of metabolic complications in obesity
(2014-11-14)
Background: Obesity is closely related to development of insulin resistance and dyslipidemia. Intrinsic properties of adipose tissue are also of great importance for obesity related comorbidity. The aim of this thesis was ...
Understanding inflammation requires neuroscience
(2022-03-01)
Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central ...
Neuroinflammatory biomarkers in suicidal behavior
(2016-03-21)
Immune dysregulation is of importance in the pathophysiology underlying psychiatric disorders including major depression, bipolar disorder, and schizophrenia. Neurobiological alterations such as a dysregulated stress-hormonal ...
Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis
(2004-03-05)
This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is ...
Adjuvant tamoxifen and luteinizing hormone-releasing hormone agonists in premenopausal breast cancer : on long-term benefits and side effects in a randomised study
(2012-10-08)
Adjuvant endocrine therapy improves breast cancer survival, unconditional of other treatment. In premenopausal breast cancer, tamoxifen for 5 years is the standard treatment, with or without the addition of ovarian ablative ...
Chronic kidney disease : a clinical model of premature vascular aging
(2021-04-27)
Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. ...
Immune mechanisms and potential immunological treatment in atherosclerosis
(2022-05-11)
Our immune system is an important and central part of the defence mechanisms of our body. It carries out various important functions such as protecting us from invading microorganisms, removing dead cells, and producing ...
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(2017-07-25)
The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ...