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Improved malaria case management in under-fives in the era of Artemisinin-based combination therapy in Tanzania
(2010-05-26)
Early parasite-based diagnosis of malaria prior to treatment is critical for rational drug use, optimal outcome of febrile illness, patient adherence, prevention of parasite drug resistance, and reduced costs of health ...
Programming of cardiovascular and metabolic functions by thyroid hormone signaling
(2014-09-26)
Thyroid Hormones (TH) regulate myriad processes, such as development, metabolism and cardiovascular functions, by controlling gene expression through binding to nuclear thyroid hormone receptors, TRα and TRβ. While patients ...
The role of ABC transporters and inflammation in drug-resistant epilepsy
(2017-11-16)
This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation. With regard to ...