Search
Now showing items 1-10 of 12
Efficiency of aerobic exercise training in women and men with chronic heart failure
(1998-05-12)
in order to acquire the knowledge needed for planning efficient exercise-based rehabilitation for women and men with CHF.
A total of 16 women and 27 men (age 41-73 years) with CHF in NYHA functional classes II-III (LVEF < 40%) participated in the trials...
On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients
(1998-05-22)
The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is ...
Prognostic and epidemiological factors in childhood leukemia : studies of p53 and MDM2 expression and of space-time clustering
(2000-05-05)
and relapsed leukaemia. p53 protein was expressed in 12 patients and MDM2 in 17 patients. To put this in perspective, we investigated p53/MDM2 expression at diagnosis in 31 children who had maintained a long-term remission of ALL. Of these patients only 4 cases...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of ...
Osteoporosis in elderly women in primary health care
(2007-10-19)
of calcium and 400 IU of vitamin D3. Bone mineral
density measurements: The bone mineral densities (BMD) of the hip and
lumbar spine (L1 L4) were determined using Hologic QDR 4500 equipment for
DXA. The peripheral measurements on the calcaneus were performed...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Investigation of the genetic basis of familial non-BRCA1/2 breast cancer
(2005-12-30)
Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully ...
RNA systems for NMR studies in vitro and in vivo
(2022-04-05)
NMR spectroscopy is an excellent tool to study the structure-function relationship of RNA. Such measurements are usually performed in vitro, which requires large amounts of isotope- labeled sample in high purity and can ...
Innate immunity in progressive multiple sclerosis
(2015-10-26)
Multiple sclerosis is (MS) is a chronic inflammatory autoimmune disease of central nervous system (CNS)
leading to demyelination, axonal damage and neurological handicap, often affecting young adults. A majority
of ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...