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Innate immunity in progressive multiple sclerosis
(2015-10-26)
Multiple sclerosis is (MS) is a chronic inflammatory autoimmune disease of central nervous system (CNS)
leading to demyelination, axonal damage and neurological handicap, often affecting young adults. A majority
of ...
The Wnt pathway in ventral midbrain dopaminergic differentiation
(2010-12-17)
Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective ...
Challenges in access and provision of medical aid for children after natural disasters in low and lower-middle income countries : a scoping review
(2016-10-05)
Background: The impact of natural disasters on human populations has become an area of particular interest in global health. Climatic changes have led to an increased frequency of such catastrophes. Although the number of ...
Progressive elements in type 2 diabetes, studies on secondary failure and diabetic complications
(2008-12-26)
Diabetes is a progressive disease with late complications, one of the most common being diabetic neuropathy (DN). DN can lead to serious complications and accounts for more hospitalization and higher costs than all other ...
Studies on the regulation of hepatic and intestinal lipid metabolism
(2013-09-25)
Disturbances in the lipid homeostasis can result in a wide variety of different diseases and symptoms. This thesis is focused on the regulation of cholesterol metabolism and its relation to atherosclerosis development, and ...
Prevention of liver cancer in chronic liver disease : an experimental study of sodium selenite and rat hepatocarcinogenesis
(2011-11-21)
Selenium treatment in supranutritional but subtoxic doses has previously been shown to inhibit cell proliferation in preneoplastic lesions in a rat liver carcinogenesis model. The mechanisms are not known, but thioredoxin ...
Human papillomavirus as a target for cancer prevention
(2021-05-12)
If we would know more about virus causing cancer, we would have the possibility to prevent the disease. Human Papillomavirus (HPV) causes cervical cancer and is one of the world’s most common sexually transmitted diseases ...
Role of mitochondrial ribosomal protein S18-2 in cancerogenesis and in regulation of stemness and differentiation
(2017-05-02)
Mitochondria carry their own ribosomes (mitoribosomes) for the translation of mRNA encoded by mitochondrial DNA. The architecture of mitoribosomes is mainly composed of mitochondrial ribosomal proteins (MRPs), which are ...
Prevention of cervical cancer through use of liquid-based cytology and supplementary HPV testing in population-based screening
(2011-04-15)
The aim of this project is to evaluate an alternative screening strategy using liquid- based cytology (LBC), and supplementary detection of human papillomavirus (HPV) in cases of minor cytological abnormalities (atypical ...