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RNA systems for NMR studies in vitro and in vivo
(2022-04-05)
NMR spectroscopy is an excellent tool to study the structure-function relationship of RNA. Such measurements are usually performed in vitro, which requires large amounts of isotope- labeled sample in high purity and can ...
Ultrasound-guided in utero lentivirus transduction of the murine nervous system to investigate nervous system disorders
(2022-05-18)
Neurodevelopment is a highly dynamic process involving hundreds of molecular different cell types. Gain and loss of function studies provide valuable insight into the gene regulatory networks that orchestrate this morphological ...
Molecular mechanisms in idiopathic inflammatory myopathies
(2014-09-19)
Background: Myositis is a group of rare autoimmune diseases. Muscle weakness and fatigue
are the dominant symptoms and inflammation with T cells and macrophages is a
characteristic finding in muscle tissue. ...
Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis
(2014-02-10)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell ...
Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development
(2007-02-16)
Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and ...
Risk factors and outcomes in inflammatory myopathies
(2023-05-04)
Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available ...
Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system
(2009-10-02)
Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms ...
Cardiovascular risk assessments in peripheral arterial disease : results of a ten-year follow-up of a Swedish population-based cohort
(2021-05-20)
Background: An updated knowledge on natural history in Peripheral Arterial Disease (PAD) is lacking, in particular for the asymptomatic stage (APAD). The disease has strong associations with other atherosclerotic manifestations ...