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Functional analysis of ligand recognition by the glucocorticoid receptor
(2000-04-14)
The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. The C-terminal domain binds the ...
Synthetic pulmonary surfactant : effects of surfactant proteins B and C and their analogues
(2010-08-19)
Pulmonary surfactant is a lipid/protein mixture lining the air-liquid
interface in the alveoli. Its main function is to lower surface tension
during respiration and thereby prevent alveolar collapse at
end-expiration. ...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
and CCR5 are prerequisite for controlling the migration of monocytes/macrophages into inflammatory foci. The role of fractalkine (CX3CL1) and its receptor CX3CR1 in the CNS is more unclear, but their expression pattern suggests a role in neuron...
Biopsies, diagnosis and prognosis in prostate cancer
(2011-11-01)
Prostate cancer is the third most common cancer in men worldwide, and poses a challenge both for patients and health care systems. Many aspects of prostate cancer are controversial, from screening for early detection to ...
Molecular mechanisms in synaptic vesicle recycling
(2010-09-03)
Neurons communicate through specialized contacts called synapses, which consist of pre- and postsynaptic compartments separated by a narrow synaptic cleft. The stimulus- dependent rapid influx of calcium ions into the ...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Immunoprecipitation Mass Spectrometry of Endogenous proteins (RIME) approach, showing that the most enriched Fra-1 interacting protein was DDX5. The cistrome and transcriptome of DDX5 extensively overlapped with that of Fra-1, which is highly associated with the TNBC...
Structural enzymology of oxalate degradation in Oxalobacter formigenes
(2008-01-04)
Oxalic acid, as one of nature's most highly oxidised compounds, is toxic
to most organisms. It is introduced in the human body in the diet but
also as a waste product of cellular metabolism. Mammals do not posses ...
Intelligence and cardiovascular health : epidemiological studies of swedish men
(2010-08-20)
Aim: A first aim of this thesis was to examine the relationship between intelligence in early adulthood and health outcomes, mainly cardiovascular morbidity and mortality, CVD, later in life using register-based data on ...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% of the cells within a...
A study of incidence, causative factors, symptoms, and prognosis in epilepsy with onset in the first two years of life
(2022-05-19)
Background: The motivation to start this thesis work came from the meetings with infants just having presented with epileptic seizures and from speaking to their parents. I found two issues to be particularly urgent. The ...