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Immunity and immunosuppression in the tumor-host interaction
(1999-11-25)
With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving ...
Multiple circuits controlling the versatility of locomotion : molecular and connectivity principles in zebrafish
(2022-11-24)
Locomotion is produced by neuronal circuits in the spinal cord. These motor circuits rely on the activation of supraspinal centres and transform descending excitatory drive into coordinated rhythmic activity. Far from ...
Lipids and autoimmunity in atherosclerosis and cardiovascular diseases
(2009-02-20)
in vitro with results confirmed by mass spectrophotometry. In contrast to native CL, oxCL can significantly induce ICAM-1 and VCAM-1 expression on HUVECs; activate intracellular calcium mobilization and induce production of leukotrienes (LTB4...
Pharmacoepidemiologic studies of drug safety in pediatric chronic inflammatory disease
(2021-05-26)
Safety evidence for use of pharmaceutical drugs in children, including treatments for serious conditions such as chronic inflammatory diseases, is generally scarce. Off-label use is common and clinicians need to rely on ...
Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1
(2004-09-10)
The Herpes Simplex Virus 1 (HSV-1) US3 protein kinase is part of the anti-apoptotic arsenal that salvage HSV-1-infected cells from damage caused by different stimuli. The Us3 gene encodes a protein kinase that phosphorylates ...
Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation
(2014-08-11)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens ...
Pathophysiology in postterm pregnancy : epidemiology, risk factors and cervical ripening
(2012-05-07)
with real-time PCR (RT-PCR). Immunohistochemistry was performed to analyze expression and distribution of cytokines (IL- 1β, IL-6, IL-8, IL-10 and IL-18), prostaglandin receptors (EP1-4 and FP) and stroma factors (CTGF, calgranulin B, furin and ALOX 15...
Female autism phenotypes : sex/gender differences in functioning, camouflaging, and eating problems
(2023-05-02)
Background: Autism is a neurodevelopmental condition defined by challenges in social interaction and communication and presence of repetitive patterns in behavior, interests, and activities alongside sensory processing ...
A 'new public health' perspective on building competence for end-of-life care and communication : how death literacy can be developed and measured
(2022-08-19)
Background: Due to aging populations and prolonged dying trajectories in many high-income countries including Sweden, more people will need extended periods of care and support at the end-of-life (EOL). In light of these ...
Dying to talk : methods and tools for conversations about dying, death and advance end-of-life care planning
(2021-04-15)
Introduction: Advance care planning has been described as a process of reflection and discussion about values and preferences for future end-of-life care. In Sweden, advance care planning is rarely systematically practiced ...