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Pathophysiology in postterm pregnancy : epidemiology, risk factors and cervical ripening
(2012-05-07)
Background: Postterm pregnancy, defined as a pregnancy of 42 or more completed weeks of gestation, occurs in approximately 5-10 % of all pregnancies. The condition is associated with increased maternal and fetal morbidity ...
Cognitive performance in old-age depression
(2015-09-10)
Study I assessed the influence of depression severity on cognitive performance, while controlling for a range of clinical and demographic factors. Individuals with moderate/severe depression exhibited deficits in multiple ...
Streptococcus pyogenes infections and toxic shock syndrome : molecular epidemiology and immunotherapy
(2006-03-08)
Streptococcus pyogenes, also known as group A streptococcus (GAS), is an important human pathogen causing a wide variety of diseases. One of the most severe diseases is streptococcal toxic shock syndrome (STSS), which is ...
Targeting MYC and CDK2 in cancer : impacts on senescence, apoptosis and immune modulation
(2021-05-27)
Cancer is a disease in which cells acquire the ability to divide uncontrollably and invade other tissues. An important component of this process is the activation of oncogenes and inactivation of tumor suppressor genes. ...
Gene targeting and delivery of therapeutic oligonucleotides
(2017-01-11)
Research in gene therapeutic strategies involving oligonucleotides (ONs) constitutes a growing field with several clinical products already approved and many more under intense investigation. The recent advances have mainly ...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
The panorama of infections in immunocompromised patients and in patients with an increased susceptibility to infections
(2013-10-31)
The main objective of this thesis was to contribute to immunomodulatory interventions that are important for the clinical outcome in patients undergoing haematopoietic stem cell transplantation (HSCT) and in patients with ...