Search
Now showing items 1-10 of 29
Effects of nicotine on mesolimbocortical dopaminergic neurotransmission : a pharmacological study in the rat
(1998-01-02)
Tobacco-smoking represents a form of drug addiction to nicotine (NlC) and the reinforcing and dependence-producing properties of NIC depend largely on central dopamine (DA) neurons, located in the ventral tegmental area ...
Sickness absence among patients with chronic pain in Swedish specialist healthcare
(2021-12-20)
Background: Chronic pain beyond three months is a global public health problem. Every third adult suffers from a chronic pain condition, resulting in a socioeconomic burden that corresponds to 3-10% of gross domestic product ...
Perioperative risk factors and outcomes
(2020-11-24)
Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ...
Translational studies of drug-induced tumor cell death
(2006-09-29)
It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function
(2001-08-10)
Cardiovascular disease is the leading cause of mortality in the world. Even though death rates are today dropping in the developed countries, disability due to the disease is rising worldwide. The major portion of ...
Human muscle response to sprint exercise and nutrient supply with focus on factors related to protein metabolism
(2016-12-21)
The overall aim of the present thesis was to study the muscular response to repeated bouts of 30-s sprint exercise. This type of exercise gives rise to a profound metabolic perturbation that might counteract an exercise-induced ...
Influenza specific T- and B-cell responses in immunosuppressed patients
(2015-04-15)
restricted CD8 T-cells were enumerated over the course of a natural pandemic influenza infection and Pandemrix® vaccination in a prospective study reported in Paper IV. PBMCs from vaccinated control individuals exhibited a significantly increased percentage...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...