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G1-phase cyclin expression in neoplastic B cells
(2002-08-16)
By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the ...
Perioperative risk factors and outcomes
(2020-11-24)
Perioperative complications is an increasing issue worldwide, as surgical volume continues to grow. Myocardial and kidney injury, and myocardial infarction (MI), are known complications in non-cardiac surgery. Hemodynamic ...
Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis
(2014-02-10)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell ...
Aspects of Hirschsprung disease
(2016-04-22)
Hirschsprung disease (HSCR) is a congenital defect of the enteric nervous system characterized by a lack of enteric neurons in the distal hindgut. Motility disturbances in the distal colon usually lead to neonatal intestinal ...
Antibody- and osteoclast-dependent mechanisms of chronic pain
(2022-02-14)
Chronic pain is a frequent condition that affects approximately 20% of worldwide population with a higher prevalence among women. Due to the lack of optimal treatment, chronic pain leads to decreased life quality as well ...