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Effects of nicotine on mesolimbocortical dopaminergic neurotransmission : a pharmacological study in the rat
(1998-01-02)
Tobacco-smoking represents a form of drug addiction to nicotine (NlC) and the reinforcing and dependence-producing properties of NIC depend largely on central dopamine (DA) neurons, located in the ventral tegmental area ...
Pancreatic beta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance
(2019-02-14)
Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function ...
Hypoxia in arterial and venous specification during vascular development
(2009-08-14)
A developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later ...