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From basic science knowledge to clinical understanding
(2010-04-02)
The aim of the thesis was to expand our understanding of medical students learning of medicine through a longitudinal perspective on the medical curriculum. The development of medical knowledge was illustrated through ...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...
A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Gene complexes and regulatory domains in metazoan genomes
(2007-11-02)
Despite the recent massive increases in genome and transcript sequence data, including wholegenome sequences for humans and many other metazoans, our understanding of the content of these sequences is far from complete. ...
The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
(2008-03-28)
This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least ...
Genetic analysis of human astrocytic gliomas : xenografts as a research tool
(1999-11-26)
in 207 astrocytic gliomas from patients, 23 glioblastoma xenografts and 13 glioma cell lines. Homozygous deletions were found in 7% of the glioblastomas and 40% of glioblastomas showed mutation of a single retained allele. The mutations mainly affected...
On methods of evaluation of lower extremity eccentric muscle performance and loading
(1995-11-03)
was greater in the dancers (x =2.07) compared with the controls (x =1.74) (p<0.001).
The isokinetic technique used quantifies isolated muscle performance. When studying functional loading, the implementation of a comprehensive approach may be more...
Smoking, smoking cessation and fracture risk in elderly women followed for 10 years
(2015-09-07)
fractures, alcohol habits, bone mineral density (BMD), use of corticoids, vitamin D, bisphosphonates, and previous falls, former smokers had an increased risk for proximal humerus fracture (HR 2.07; 1.19–3.57) and current smokers had an increased risk...
Parental cancer diagnosis and child mortality : a population-based cohort study in Sweden
(2017-03-27)
-cancer-related (HR: 1.43; 95% CI: 1.14-1.79) and cancer-related (HR: 2.07; 95% CI: 1.33-3.24) death in the exposed children.
CONCLUSION: Children have an increased rate of death if they have a parent diagnosed with cancer as compared to children without...