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Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia
(2001-09-21)
elevation (3-5 fold) of endogenous kynurenic acid levels was associated with increased firing rate and burst activity and a decreased regularity of firing of midbrain dopamine (DA) neurons. These actions were reversed by treatment with D-cycloscrine (128 mg...
Paediatric intensive care in Sweden : i mechanical ventilation and central haemodynamics : ii outcome of paediatric intensive care with special reference to respiratory failure
(2008-05-23)
The ABC of acute care is to maintain Airway, Breathing and Circulation or
oxygen delivery, which depends on the product of cardiac output (CO) and
oxygenation. Thus knowledge of how different modes of mechanical
ventilation ...
Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments
(2011-12-21)
the interaction with cell surface structures and extracellular molecules. IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-Asp (RGD) sequence, and IGFBP-1 has been shown to increase migration independently of IGF-I by binding to extracellular α5β1-integrins. An IGFBP...
Regulation of Plasmodium falciparum virulence genes and immune response to surface antigens in placental malaria
(2011-11-15)
. falciparum erythrocyte membrane protein 1 (PfEMP1) VAR2CSA is the main adhesin involved in placental malaria. We investigated the differential recognition of various VAR2CSA DBL-domains by immune sera from pregnant women and found DBL5ε to be widely...
Tick-borne encephalitis : clinical and pathogenetic aspects
(2015-11-25)
in 43.6%, 43.6% and 12.8%, respectively. Paralytic disease was observed in 3.8%, and cranial nerve injury in 5.3% of the TBE patients. Permanent CNS dysfunction after 1 year was found in 30.8% of patients; in 8.5% of all TBE cases, severe disabilities...
Exercise strategies to improve aerobic capacity, insulin sensitivity and mitochondrial biogenesis
(2014-10-15)
Regular exercise plays a key role in the maintenance of health and physical capabilities. Extensive research shows that exercise is an efficient method to prevent diabetes. Both resistance and aerobic exercise training are ...
Long-term follow-up after treatment of invasive and in situ breast cancer : aspects on second breast cancers HRQOL and lymphoedema
(2014-02-28)
Breast cancer is the most frequent cancer among Swedish women and in 2012, 8490 new inva- sive breast cancers were diagnosed. The incidence of in situ breast cancer has markedly in- creased since nationwide mammography ...
Genetic regulation of neuroinflammation after infection and injury
(2012-05-16)
for innate immune responses occurring without an infectious trigger. We identified two quantitative trait loci (QTLs) on chromosome 1 (Neuinflam4) and 7 (Neuinflam5), respectively, regulating major histocompatibility complex class II (MHC II) expression after...
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
(Nature Publishing group, 2022-08-18)
Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...
Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting
(2013-11-07)
Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration ...