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Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia
(2001-09-21)
Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain.
The aim of the present work ...
Lymphangiogenesis and lymphatic metastasis
(2005-11-18)
The major cause of cancer mortality is metastasis, which relies on the growth of blood vessels (haemangiogenesis) and lymphatic vessels (lymphangiogenesis). Whereas the field of haemangiogenesis has been relatively thoroughly ...
Pre-analytical errors in blood sampling procedures in paediatric hospital care
(2022-01-14)
Introduction: Blood tests are important for diagnosing and treating children who are hospitalised with illnesses. The blood test process follows the specific phases of pre-analysis, analysis and post-analysis. Most blood ...
From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes
(2020-05-18)
Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...