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Anticipating, experiencing and valuing the transition from worker to retiree : a longitudinal study of retirement as an occupational transition
(2000-04-14)
The general aim of this thesis was to explore and understand the retirement process from an occupational perspective. Exploration of the retirement process included attitudes, preparations and expectations before retirement, ...
Tick-borne encephalitis : clinical and pathogenetic aspects
(2015-11-25)
The aims of this study were to investigate the morbidity associated with tick-borne encephalitis (TBE) in the acute stage and at long-term follow-up, to identify the possible host risk factors for development of clinical ...
Studies on the role of SOCS3 and STAT3 in development and function of the immune system
(2017-11-27)
The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Novel aspects of atherosclerosis : focusing on new target genes and the effect of cholesterol-lowering
(2017-12-15)
Atherosclerosis is most often the main underlying cause of cardiovascular diseases (CVDs), accounting for more than 31% of all deaths worldwide. It is driven by the uptake of low-density lipoproteins (LDL) by a dysfunctional ...
The involvement of INSIGs, DGAT1 and APOB in human lipid metabolism
(2008-10-03)
Atherosclerosis is a complex pathophysiological condition characterized by lipid accumulation in the vascular wall. These lipids are derived from the lipoproteins present in the circulation. Two major plasma lipoprotein ...
Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism
(2009-11-06)
Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain ...