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Evaluation of new and current preventive strategies for cervical and vaginal cancer
(2024-05-08)
This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ...
Thioredoxin-1 in Alzheimer disease
(2015-11-05)
Oxidative stress is one of the earliest signs in Alzheimer Disease (AD) brain. In order to protect themselves against oxidative stress, neurons use antioxidants as a defense mechanism. Such an antioxidant is Thioredoxin-1 ...
SNP technology and Alzheimer’s disease
(2003-02-21)
One major goal of genetic research is to understand the role of genetic variation. By far the most common type of such variation in humans involves single DNA bases, and is termed single nucleotide polymorphism (SNP). With ...
Stimulating neuroprotective and regenerative mechanisms in Alzheimer disease
(2013-08-14)
The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions. Mechanisms that stimulate, manage and regulate ...
Studies on gamma-secretase activity and products
(2010-02-26)
gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein ...
A multi-tracer PET approach to study early-onset familial and sporadic Alzheimer's disease
(2011-09-16)
Cumulated scientific evidence suggests that the pathology causing Alzheimer's disease (AD) occurs many years or even decades before memory impairment and other clinical symptoms arise. Tangible and detailed knowledge about ...
Search for reliable diagnostic markers for Alzheimer’s disease
(2000-04-28)
The diagnosis of Alzheimer’s disease (AD) is rather difficult not at least in the earlier stages of the disease. The diagnostic accuracy has been reported to be around 65-90%. These figures however, come from academic ...
Inflammation as a therapeutic target for Alzheimer's disease
(2010-04-02)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder
which is characterised by impairment of memory and learning. The
impairment is caused by neuronal death which originates in the parts of
the brain ...