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Combined oral contraceptives : impact on the vulvar vestibular mucosa and pain mechanisms
(2007-08-24)
Objective: The main aim of this thesis was to study the impact of
combined oral contraceptives (COC) on the vulvar vestibular mucosa and
pain mechanisms; in healthy women and in women with provoked
vestibulodynia (former ...
Hypoxia in arterial and venous specification during vascular development
(2009-08-14)
A developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later ...
Vascular development : from embryonic stem cells to arteries and veins
(2008-11-14)
A fundamental question in developmental biology is how a single
fertilized egg cell and its progeny are programmed or instructed to form
thousands of different cell types and how these are organized into a
complex and ...
Redox and epigenetic modulators regulate cardiac function and remodeling in health and disease
(2023-09-22)
Oxidative species are a divergent group of cellular metabolites with a wide variety of functions. Together with reductants, they regulate almost all cellular functions, from mediating cellular communications to catalyzing ...
Impairment of B cell trafficking and differentiation during HIV-1 infection
(2011-10-05)
During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number ...
The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways
(2014-09-26)
The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. ...
Significance of adipose tissue characteristics for development of metabolic complications in obesity
(2014-11-14)
Background: Obesity is closely related to development of insulin resistance and dyslipidemia. Intrinsic properties of adipose tissue are also of great importance for obesity related comorbidity. The aim of this thesis was ...
Exosomes in immune regulation and allergy
(2007-04-20)
Exosomes are nano-sized vesicles of endosomal origin which are secreted from several different cell types. Depending on their cellular source they have been suggested to have different functions, like having a role in ...
Glossopharyngeal breathing
(2008-03-21)
Introduction and aims: The technique of glossopharyngeal breathing was introduced already in the 1950 s, but today, few health professionals are aware of its uses. The technique is performed by using the glossopharyngeal ...
Congenital CMV infection and connexin 26 mutations in childhood deafness : intervention with early cochlear implantation
(2013-11-22)
Hearing impairment (HI) is a common disability, which affects a significant proportion of the population. Early in life, however, the risk of acquiring a HI is low, with 0.2 % of all newborns having a permanent HI, and of ...