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Severe hypoxemia during apnea in humans : influence of cardiovascular responses
(2002-09-13)
When a diving human holds his or her breath, the heart beat slows and the blood vessels constrict in large portions of the body. In diving mammals such as seals, similar responses effectively conserve oxygen for the brain, ...
Potential overtreatment during life-limiting illness and end of life in older adults
(2023-10-11)
Background. A growing body of evidence suggests that older patients are subject to potential overtreatment at the end of life, characterised by disease modifying therapies, preventive medications, and frequent care ...
Epithelial stem cells in Hutchinson-Gilford progeria syndrome
(2015-01-07)
Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare
genetic disorders that affect children. Complications from cardiovascular disease, including
atherosclerosis, are the most common ...
PCR and sequencing based methods for detection and typing of pathogenic microorganisms
(2011-11-18)
The potential use of bacteria and viruses as biological terror weapons makes certain highly pathogenic microorganisms a worldwide public health threat. In an outbreak investigation involving a possible deliberate spread ...
Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line
(2005-03-25)
The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs ...
Molecular diagnosis of infection with Toxoplasma gondii in immunocompromised patients
(2006-08-23)
The protozoan parasite Toxoplasma gondii infects more than a billion people worldwide. The parasite is generally divided into three clonal lineages, denoted type I, II and III. Primary infections in humans are usually ...
Post-translational modifications of proteins in human breast cancer : proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis
(2011-11-11)
Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to ...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Aspects of chemotherapy and photon and proton radiotherapy in patients with gastric cancer
(2015-02-13)
Gastric cancer remains a major health problem worldwide. The addition of chemotherapy
alone or in combination with radiotherapy to surgery in local gastric cancer improves
outcome. In more advanced stages, the optimal ...
Infections in skin cancer
(2016-03-07)
The increasing prevalence of skin cancer results in that it will soon equal that of all other
cancers combined. Sun exposure is a well-known risk factor for its development, but
despite the growing public awareness of ...