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Translational studies on antimetabolic therapies in paediatric oncology
(2023-08-15)
Cure rates for paediatric and adult cancer patients have improved within the last
decades. This can partly be explained by implementation of new technologies and
methodologies such as the identification of new mutations ...
Single cell studies of human T cell function with applications for HIV-1
(2016-04-18)
T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
Dysfunctional phenotype of T cells and their contribution to impaired B cell function during HIV-1 infection
(2016-08-29)
Microbial translocation and increased immune activation have been involved in functional T cell impairments and disease progression during HIV-1 infection. The impact of microbial translocation on the phenotype of memory ...
Emotional orientation, brain function and genetics in adults and children : implications for development, and psychopathology
(2011-01-19)
The ability to attend or avoid emotional stimuli is important to our survival. Attending to potential threats can help us avoid danger; while attending to positive stimuli is important for our social function. For example, ...
Diagnosis and treatment of Helicobacter pylori infection in Vietnamese children
(2009-11-20)
Aim: The aim of the study was to find the optimal H. pylori eradication therapy for children in Vietnam, a developing country. Therefore, we evaluated a non-invasive diagnostic method and antibiotic susceptibility of H. ...
Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis
(2016-08-18)
Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined ...