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Preschool asthma : infant lung function, inflammation and skin barrier function in early life
(2023-08-18)
Background: Asthma is among the most common obstructive respiratory disorders in children, characterized by airway inflammation with features such as wheeze, cough and shortness of breath. Though the etiology behind the ...
Osteoporosis in elderly women in primary health care
(2007-10-19)
Objective: All the studies are parts of the PRIMOS (Primary Health Care
and Osteoporosis) project. Study I investigates the relationship between
central Dual X-ray Absorptiometry (DXA) measurements of the hip and spine
and ...
Characterization of extracellular and surface bound adherence proteins of Staphylococcus aureus
(2012-11-02)
Staphylococcus aureus (S.aureus) is a pathogen causing infections. In recent years S.aureus formed resistance to most of known antibiotics on the market. It is today a global interest to find alternative treatment against ...
Adipose tissue inflammation and coagulation in humans
(2010-10-01)
Background: Adipose tissue (AT) is not only a store of energy but an endocrine organ with capacity to produce and release proinflammatory mediators into the circulation. Obesity is an inflammatory disease, with increased ...
Environmental factors and risk of acoustic neuroma
(2014-05-19)
The aim of this thesis was to increase the knowledge about environmental risk factors of acoustic neuroma and to increase the understanding of the methodological problems encountered when studying this tumor.
Acoustic ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular ...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear ...
Integrin-interacting proteins in human cancer progression
(2010-04-02)
Integrins are the major transmembrane receptors for the extracellular matrix (ECM) which regulate a diverse array of cellular functions crucial to tumor cell migration, invasion, proliferation and survival. Integrins contact ...
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
(2014-05-19)
Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance ...
Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection
(2006-04-14)
B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against ...